It’s becoming a given — whether you’re stuck in a traffic jam on your way to work, arguing with your partner over finances, coordinating the family’s busy schedule, or having difficulty turning down your racing thoughts at night, most of us encounter daily stresses. According to the National Institute of Health, 40 million adults in the US have anxiety disorders.  These can range in severity from Generalized Anxiety Disorder and Social Phobia to more extreme versions including Panic Disorder, OCD, and Post Traumatic Stress Disorder.
Traditional treatments for anxiety disorders have included a class of medications known as benzodiazepines (Xanax, Valium). However, many clinicians have growing concern over prescribing such medications due to their addictive nature and impact on cognition. New reports are emerging that demonstrate a direct correlation of benzo use to an increased risk of Alzheimer’s Disease. A recent study published in the British Medical Journal showed “the risk of Alzheimer’s disease was increased by 43-51% among those who had used benzodiazepines in the past. Risk increased with density of exposure and when long acting benzodiazepines were used”. 
With these statistics in mind, many Nootropic enthusiasts have focused attention for anxiety relief on a particular class of Nootropics, peptides.
A peptide is a chemical compound containing two or more amino acids that are coupled by a peptide bond. There are 20 naturally-occuring amino acids and they can be combined together to form new molecules. When a molecule consists of 2-50 amino acids it is called a peptide, whereas a chain of 50 or more amino acids is referred to as a protein.
Discovery of Selank
Research on peptides began in the 1970’s in Russia following the UN “Convention on Psychotrophic Substances” that essentially banned drugs traditionally used by militaries worldwide. This ban included amphetamines, a widely employed wakeful and focusing drug. The Ministry of Russian defense tasked the Research Institute of Molecular Genetics in Moscow to develop comparable chemical agents. It was at this time Nikolai Myasoedov, a researcher at the institute, focused his attention on endogenous compounds, peptides, to provide harmless stimulation.
Dozens of molecules previously unexplored came to light out of this research, including Tuftsin (aka TP-1), a tetrapeptide produced primarily in the spleen. The researchers discovered that this peptide had nootropic, anxiolytic and immunostimulating effects
The researchers found out that they could prevent premature decomposition of the molecule by attaching a ‘tail’ of amino acids to the tuftsin molecule. Selank (formerly TP-7) is born.
Clinical trials on this novel compound concluded in 2004 and Selank was proven effective for treating an array of anxiety disorders. In addition, many patients were able to conquer their fears coupled with “improved mood, mental and motor activity, and most importantly, Selank was demonstrated as not addictive”. 
According to research provided by the Institute of Molecular Genetics, drops “that must be instilled into the nose” is still considered the best way to take neuropeptides. With this in mind, a >1% solution of Selank can be prepared for sterile instillation.
My experience with Selank
I have personally t.i.d.Selank on several occasions to help quell feelings of anxiety and have found it to be quite effective. 400 mcg instilled intranasal provided me with several hours of great clarity, focus, and organized thought. My mind doesn’t feel cloudy or groggy like I’ve experienced from other anxiolytics, mood is noticeably improved, and a slight energy lift is detectable. In my opinion, Selank is a viable treatment option for those suffering from anxiety and for certain aspects of motivation especially those with an inability to see projects through to completion.
References [ + ]
|1.||↑||Anxiety Disorder Among Adults|
|2.||↑||Benzodiazepine use and risk of Alzheimer’s disease: case-control study|
|3.||↑||What are Peptides|
|4, 5, 6, 9, 10, 11.||↑||Закапать в нос бесстрашие (translated from Russian)|
|7.||↑||(1987) Taftcine-like peptides modulatory action on rat escape behavior in acute stress situation, In Biostimulators. Belozertzev. A. V. (ed.)|
|8.||↑||The characteristics of the anxiolytic action of taftsin and its analog TP-7 on behavior and serotonin metabolism in the brain of rats with chronic deprivation of serotoninergic system activity.|