The concept of "nootropic" substance - that is, a drug that enhances memory and cognition - was developed by Corneliu E. Giurgea, a chemist who also synthesized piracetam, the first nootropic.
Fasoracetam is the newest racetam and one of the most potent nootropics yet discovered. It is currently being studied as a non-stimulant ADHD treatment, but it may also work as an antidepressant nootropic.
Methylene blue supports mitochondrial respiration and strengthens synaptic connections, which may lead to decreased fatigue and enhanced cognition & recall.