The consensus is that a reasonable tianeptine sulfate dosage is 25mg, or 2x the starting dose of tianeptine sodium. An excellent review of tianeptine sulfate (by an expert psychopharmacologist/philosopher) can be found here.
Keep in mind that the pharmacodynamics of tianeptine sodium remain uncharacterized, so the tianeptine sulfate dosage of 25mg is based on anecdotal reports from users, not on evidence. Some individuals have used higher tianeptine sulfate dosages without apparent ill-effect, but this should practice should not be assumed to be safe.
Tianeptine sulfate is just like Tianeptine sodium, only differing with respect to its counter-ion. Since tianeptine has a carboxylic acid group (COO-), which is negatively charged, a tianeptine salt can be formed with sodium, which is positively charged, forming an overall neutral ionic compound.
Tianeptine sulfate is formed by acidifying tianeptine with hydrogen sulfate (HSO4-, also known as bisulfate). Hydrogen sulfate is a weak acid that protonates the carboxylic acid and the basic nitrogen atom in Tianeptine. Tianeptine cannot be acidified with sulphuric acid because sulphuric acid is a very strong acid.
Tianeptine sulfate vs Tianeptine Sodium
What’s the difference between tianeptine sulfate vs tianeptine sodium?
Apart from the obvious chemical difference (discussed above), the significant differences are:
- Stability. Tianeptine sodium is unstable and decomposition occurs in the presence of light, heat and moisture. Tianeptine sulfate appears to be more stable.
- Half-life. Tianeptine sulfate has a longer duration of action (tianeptine sodium only lasts 2-3 hours; tianeptine sulfate lasts all day).
- Potency. To achieve the same effects, roughly twice the tianeptine sulfate dosage is needed.
- Physical properties. Tianeptine sodium is extremely hygroscopic (it absorbs moisture from air); tianeptine sulfate is not hygroscopic.
- Absorption. In this case, tianeptine sulfate’s inefficient absorption and excretion is an asset, because it delays release in a controlled fashion resulting in a longer duration.
- Hygroscopicity. Tianeptine sodium is extremely hygroscopic. It will suck moisture from air at an alarming rate. If you’re interested in the chemistry underlying this phenomena, you can read about it here.
In short, because tianeptine sodium is so hygroscopic, it is cumbersome to store for very long. It begins to degrade the moment it first comes into contact with air. One solution is to use dessicant packets, but your mileage will very.
Dessicant packets are comprised of silicon dioxide, which are even more hygroscopic than tianeptine sodium, which causes moisture to be absorbed by the silicon dioxide instead of tianeptine sodium. Another option is to store tianeptine sodium in a dessicator.
You can buy tianeptine sulfate at BlueBrainBoost.